Last dreams
Dream number 14367 26 January 2021 2 psychic prediction by Brian Ladd Dream number 14366 26 January 2021 1 psychic prediction by Brian Ladd Dream number 14365 25 January 2021 3 psychic prediction by Brian Ladd Dream number 14363 25 January 2021 1 psychic prediction by Brian Ladd Dream number 14364 25 January 2021 2 psychic prediction by Brian Ladd Dream number 14360 24 January 2021 9 psychic prediction by Brian Ladd Dream number 14359 24 January 2021 8 psychic prediction by Brian Ladd Dream number 14357 24 January 2021 6 psychic prediction by Brian Ladd Dream number 14356 24 January 2021 5 psychic prediction by Brian Ladd Dream number 14358 24 January 2021 7 psychic prediction by Brian Ladd Santiago Guillen Jr located - safe - US Airforce man -  not related to the Hi-Fi murders - numbers - evona - west haven Missing teen Tara Leigh Calico located safe - the photos are not her  - she is still down there being held by him  - he lives near Santa Barbara Sunrise RV Park Dream number 14355 24 January 2021 4 psychic prediction by Brian Ladd Dream number 14354 24 January 2021 3 psychic prediction by Brian Ladd Missing man Thomas Hughes located - rr - three Rivers Heritage Trail numbers Dream number 14353 24 January 2021 2 psychic prediction by Brian Ladd Dream number 14352 24 January 2021 1 psychic prediction by Brian Ladd Missing man Thomas Hughes located - behind this brick wall by the railroad tracks - numbers - was not drinking - lies - foot not broken - look again the same area Dream number 14351 23 January 2021 4 psychic prediction by Brian Ladd Dream number 14350 23 January 2021 3 psychic prediction by Brian Ladd Dream number 14349 23 January 2021 2 psychic prediction by Brian Ladd Dream number 14348 23 January 2021 1 psychic prediction by Brian Ladd YvonneMestas YuChinChangGoodson Wojciech-Fudali WookKim YeseniaRosario WinonaJDBag-277x300 WinonaJDEyepng-166x300 
Category Albums Dreams
BRIAN LADD, Schizophrenic PSYCHIC DREAMER - BIOGRAPHYPsychic Brian Ladd uses his visions, dreams to accurately predict future events. His online dream diary contains over 20,000 documented dreams, lucid dreams, and remote viewing cases. To date, over 3,000 dream predictions (including 300 plus lottery dreams) have come true, with more and more every day. Brian has personally worked on hundreds of missing person cases since 2006 with a success rate of around 45%. Brian served 12 active years in the US Army and then joined the Army Reserves. Brian was diagnosed with Schizoaffective Disorder in 2011, and some say this 'illness' maybe the reason why so many of his dreams have come true. To learn more about Brian his family and what he does (and how you can too) visit his bio page at https://briansprediction.com/about-me.php
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DREAMS THAT HAVE COME TRUEThis category includes a partial list of dreams that have recently come true. For additional confirmations, view this sites popular dream links or visit this sites archives. To date over 3,000 dreams of mine have come true including over 1,000 lottery numbers predictions.
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2021 DREAM JOURNALWell 2020 was not that great of a year, I'm hoping this year will be better.
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2020 DREAM JOURNALMy dreams from the year 2020...and I hope to stay out of the hospital a much as possible this year :)
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2019 DREAM JOURNALLooking forward to a great 2019, and I'll try my best to spend more time posting my dreams and doing personal requests...on time.
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2018 DREAM JOURNALNew websites for members is almost ready to go, also have been trying to clean up broken links and duplicate images from the non-member site and should have it completed soon. Mobile version of this site should be working satisfactory and I'm excited about all the upcoming events this year...especially the new reality TV show! Lottery number personal picks are also still available but if you still want me to pick numbers specifically for you, now is the time.

12 1,762
2017 DREAM JOURNALWill be working on new projects this year including adding recent missing person cases, remote viewings, map dowsing and more. I will be improving my VIP areas and be adding more medical cure and free subliminal downloads. For example, I have added over 200 pages of new psychic work to the Madeleine McCann missing child case and over 400 new documents that can not be found anywhere else on the web!
12 1,732
2016 DREAM JOURNALMy dream diary for the year 2016, and I'm hoping this year my dreams will make a positive impact in your life too. Dreams are for a reason, and their source does not have to come from your conscious mind...you can tune your brains receiver to access The Universal Consciousness Channel, and when you do, you will never be the same again! The most important thing I can tell you is to KEEP A PEN AND PAPER NEXT TO YOUR BED, DREAMS FADE QUICKLY, PRACTICE, RECORD, AND LOVE.
12 1,244
2015 DREAM JOURNALMost of this year was positive for me up until October 1st, this is when my younger sister, Christine, died unexpectedly of a toxic level of schizophrenia medicine and heart pills. She was my only sister and sibling and I will never be this same...talking about what dreams came true and how many lottery winners there were does not mean a thing right now.
13 927
2014 DREAM JOURNALMy dream diary for the year 2014...a much better year. I personally helped close several missing person cases, was thanked by several agencies that 'don't use psychics' and had a wonderful time with my wife and kids. I also learned, from my own dreams, a new way to do what I do better and I will share it with you asap. I cannot say this enough, forget most of what you have learned in life from others, turn off repetitive self-talk and truly love yourself and your surroundings. Your DNA can teach you what you need to know, and God will do the rest.
12 930
2013 DREAM JOURNALNightly dreams for the year 2013, this year I had over 200 dreams come true plus 98 correct lottery picks. Lots of new 'dream inventions' and 'medical breakthrough' were added this year, and I'm happy to say that many people did benefit from them. I have since opened a category for all 200 plus inventions I have dreamed about since 2005, and you're free to use any of them, but please make sure you credit the source.
10 661
2012 DREAM JOURNALThis was a bad year for me, spent some time in a mental hospital and was told the bad news about my heart.
4 43
2011 DREAM JOURNALNightly dreams for the year 2011, this year was a sad time for me...and I really didn't feel like doing anything...at all.
3 10
2010 DREAM JOURNALNightly dreams for the year 2010...missing persons...missing persons and more missing persons, we also started a missing person webcast.
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2009 DREAM JOURNALNightly dreams for the year 2009, earthquakes, hurricanes floods, and fires...they all came true...unfortunately. I started my MP TV show and Dream Talk Radio this year and learned a great deal from many of my guests.
12 270
2008 DREAM JOURNALNightly dreams for the year 2008, this year I started paying more attention to my dreams learning from them. Have dozens of health related dreams I have shared with the world.
12 528
2007 DREAM JOURNALNightly dreams for the year 2007, many earthquake predictions came true this year...so many in fact it made the news.
12 1,001
2006 DREAM JOURNALNightly dreams for the year 2006, over 80 Missing person cases were added this year and 38 of them were correct.
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2005 DREAM JOURNALNightly dreams from the year 2005, this is the first year I started putting my dream journal on line and when I actually started truly believing a person's dreams can predict future events.

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MISSING PERSONS, 2018 - 2021These are the current cases I'm working on, please check back often as I add new cases on a daily basis. 2020 other cases at https://briansprediction.com/missingall.php
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MISSING PERSONS CASES, 2005 - 2017Since 2006 I have personally worked over 1,000 missing person cases, I have literally spent thousands of hours of my own time trying to help located missing persons, especially missing children...and always for free. The cases listed here are from my old site, unfortunately, after I git sick, I lost my site and any backup copies I had, so these are direct links to archive.org's Wayback machine. In time I will transfer these old cases to my new site. I've had a pretty good track record in helping to locate loved ones, and I'm always willing to help in new cases as well. If you would like to help, please consider a small donation to my missing person's site fund @ brianladd.org/missingold To view all cases from 2006 to 2017 from the way back machine please visit brianladd.org/missingold
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FBI MOST WANTED - SOLVED CASESFBI most wanted current and past FBI most wanted case solved by Psychic Detective Brian Ladd - you must be a member to access these cases https://briansprediction.com/join

Private access is located at https://briansprediction.com/fbi
1 640
VIP MEMBERS ONLY AREADream predictions for over 75 world lotteries, winning slot machine serial numbers for almost every major casino in the world, medical cures, subliminal healing sessions by me and many more members-only services to come. VIP members also get access to censored and restricted information even if it's been deleted by 'other' sources. Non-member access to this area is very limited, around 5%, to access all material here you'll need to register first. (if slots are a available, if not please check back in few days)
61 21,553

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April 2020 Psychic Brian Ladd uses his visions, dreams to accurately predict future events. His on-line dream diary contains over 8,000 documented dreams, lucid dreams and remote viewing cases. To date, over 3,000 predictions have come true, with more and more every day. Brian has personally worked hundred missing person cases since 2006 with a success rate of around 45%. Brian served 12 active years in the US Army and then joined the Army Reserves. Brian was diagnosed with Schizoaffective Disorder in 2011, and some say this 'illness' maybe the reason why so many of his dreams have come true.
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Miracle Cures Subliminal Audio Sessions by Psychic Brian Ladd cure anything overnight weight loss better sleep death and whats nest cold flu and COVID 19 and more 5WK3M6LHK5GDTDUQF33Y4K3WOQ over 8 hours each59 views todayMy new Miracle Cures Subliminal audio sessions are ready! I have 5new 9 hours sessions ready to go, see my new site at

https://briansprediction.com/miracle-cures

weightloss - better sleep - death and whats nest - cold flu and covid 19

Eight hour subliminal cell-reprogramming audio sessions guaranteed to work while you sleep! Teach your cells to heal your body like they were supposed to do. These personalized sessions are amazing and a completely new approach to healing the body from within. I personally created each and every session using my dreams as a guide. Every session is voiced by me using hundreds of affirmations from thousands of dreams I have had since 2005. These audio sessions do work and WILL fix whatever is wrong with you. Brian Ladd

Miracle Cures Subliminal Audio Sessions by Psychic Brian Ladd cure anything overnight weight loss better sleep death and whats nest cold flu and COVID 19 and more 5WK3M6LHK5GDTDUQF33Y4K3WOQ over 8 hours each
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DANIELLE STISLICKI MISSING WOMAN FOUND SAFE MAXRESDEFAULT PSYCHIC BRIAN LADD15 views todayAnn and Richard Stislicki have awakened in their Fowlerville home to the uncertainty, the fear and the loneliness that comes with the realization their daughter Danielle is still missing.

It's been that way since Dec. 2, 2016, when Danielle, their bubbly 28-year-old daughter, left the insurance office at which she worked in Southfield, never to be heard from again. Danielle was supposed to go out with friends that night, but never showed up. Her car was found in her Farmington Hills apartment complex the next morning, but there's been no sign of her since.

That was a little more than a year ago and, though the family is doing what it must to get by, it never gets any easier. This week, with the one-year anniversary having passed Saturday, was especially difficult.

"It's a challenge. ... It was very difficult this past week to get through," Ann Stislicki said. "We started to make a commitment that we'd focus on ourselves and the family and not look at Facebook. You work through it, you talk through it as much as you can, but we all have our moments when we break down. But we're there for each other. We know we're all challenged with the struggle and (try) to keep that hope up."


Chris Paliewicz, Danielle's uncle, remembers those days, not like they happened more than a year ago, but like they were just yesterday. He was walking his dog Dec. 3, 2016, the day after Danielle went missing, when he got a call saying they needed to get into Danielle's apartment.

The day after that was spent searching for her, which has been pretty much how the ensuing 365 days have gone.
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April 2020 Psychic Brian Ladd uses his visions, dreams to accurately predict future events. His on-line dream diary contains over 8,000 documented dreams, lucid dreams and remote viewing cases. To date, over 3,000 predictions have come true, with more and more every day. Brian has personally worked hundred missing person cases since 2006 with a success rate of around 45%. Brian served 12 active years in the US Army and then joined the Army Reserves. Brian was diagnosed with Schizoaffective Disorder in 2011, and some say this 'illness' maybe the reason why so many of his dreams have come true.
Jan 27, 2021 at 11:18 PM
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My Coronavirus Miracle Cure This Homemade Diy Alternative Treatment Recipe Might Actually Work And Its Freeby Pssychic Brian Ladd044713 views todayCoronavirus miracle cure tea this homemade recipe DIY coronavirus tea alternative treatment recipe might really work and it's free My Coronavirus Miracle Cure This Homemade Diy Alternative Treatment Recipe Might Actually Work And Its Freeby Pssychic Brian Ladd0447

This is a tea to prevent and cure the current coronavirus in the world today...this what I think it says:

Take 5 cups of reverse osmosis water with a PPM of less than 20 ppm, boil for 5 minutes then add 1/2 cup of dried Honeysuckle Flowers, 1 tablespoon of apple cider vinegar, 1/4 cup of dried Huang Lian and 1 tablespoon of regular honey (any type). Boil rapidly until half the liquid is gone, drink hot 3 times a day. (and as always, never take any medical advice from me or anyone without checking with a doctor first)


Coronaviruses are a large family of viruses found in many different species of animals...including camels, cattle, and bats. A new strain of coronavirus has been identified as the cause of the outbreak of respiratory illness in people first detected in Wuhan, China. On February 11, 2020, the World Health Organization named the disease COVID-19. (Formerly, it was referred to as 2019-nCoV.) Rarely, animal coronaviruses jump species and infect people, and then possibly spread between people, such as with MERS-CoV, SARS-CoV, and now with this new virus (named SARS-CoV-2).

The media has reported that some people are seeking “alternative” remedies to prevent infection with SARS-CoV-2 or to treat the 2019 coronavirus disease now called COVID-19. Some of these purported remedies include herbal therapies and teas. There is no scientific evidence that any of these alternative remedies can prevent or cure the illness caused by this virus. Some of them may not be safe to consume.1
While scientists at NIH and elsewhere are evaluating candidate therapies and vaccines to treat and prevent the novel coronavirus, currently there are no treatments or vaccines for COVID-19 approved by the U.S. Food and Drug Administration. The best way to prevent infection is to avoid exposure to this virus. The Centers for Disease Control and Prevention (CDC) also recommends everyday preventive actions to help prevent the spread of this and other respiratory viruses, including the following:
Wash your hands often with soap and water for at least 20 seconds, especially after going to the bathroom; before eating; and after blowing your nose, coughing, or sneezing.
If soap and water are not readily available, use an alcohol-based hand sanitizer with at least 60% alcohol. Always wash hands with soap and water if hands are visibly dirty.
Avoid touching your eyes, nose, and mouth with unwashed hands.
Avoid close contact with people who are sick.
Stay home when you are sick, and keep children home from school when they are sick.
Cover your cough or sneeze with a tissue, then throw the tissue in the trash.
Clean and disinfect frequently touched objects and surfaces using a regular household cleaning spray or wipe.
If you feel sick with fever, cough, or difficulty breathing, and have traveled to China or were in close contact with someone with COVID-19 in the 14 days before you began to feel sick, seek medical care. Before you go to a doctor’s office or emergency room, call ahead and tell them about your recent travel or exposure and your symptoms.

https://briansprediction.com/coronavirus/


This is a tea to prevent and cure the current coronavirus in the world today...this what I think it says:

Take 5 cups of reverse osmosis water with a PPM of less than 20 ppm, boil for 5 minutes then add 1/2 cup of dried Honeysuckle Flowers, 1 tablespoon of apple cider vinegar, 1/4 cup of dried Huang Lian and 1 tablespoon of regular honey (any type). Boil rapidly until half the liquid is gone, drink hot 3 times a day. (and as always, never take any medical advice from me or anyone without checking with a doctor first)





Wuhan National Bio-safety Laboratory Coronovirus AI drugs psychic prediction by Brian Ladd AID research being used as bioweapons

bioweapons Wuhan Institute of Virology 中国科学院武汉病毒研究所

The Wuhan Institute of Virology 中国科学院武汉病毒研究所 is a research institute administered by the Chinese Academy of Sciences (CAS) on virology, and is located in Jiangxia District, Wuhan, Hubei, China. In 2015, the Institute opened the first biosafety level 4 (BSL–4) laboratory to be built in mainland China.

Wuhan Microbiology Laboratory
South China Institute of Microbiology
Wuhan Microbiology Institute
Microbiology Institute of Hubei Province
My Coronavirus Miracle Cure This Homemade Diy Alternative Treatment Recipe Might Actually Work And Its Freeby Pssychic Brian Ladd0447
Chen Huagui, Gao Shangyin

Wang Yanyi
Secretary of Party Committee
Xiao Gengfu[1]
Deputy Director-General
Gong Peng, Guan Wuxiang, Xiao Gengfu
Parent organization
Chinese Academy of Sciences My Coronavirus Miracle Cure This Homemade Diy Alternative Treatment Recipe Might Actually Work And Its Freeby Pssychic Brian Ladd0447
The Institute was founded in 1956 as the Wuhan Microbiology Laboratory under the Chinese Academy of Sciences (CAS). In 1961, it became the South China Institute of Microbiology, and in 1962 was renamed to Wuhan Microbiology Institute. In 1970, it became the Microbiology Institute of Hubei Province when the Hubei Commission of Science and Technology took over the administration. In June 1978, it was returned to the CAS and renamed Wuhan Institute of Virology
In 2015, the National Bio-safety Laboratory was completed at a cost of 300 million yuan ($44 million) at the Institute in collaboration with French engineers from Lyon, and was the first biosafety level 4 (BSL–4) laboratory to be built in mainland China. The laboratory took over a decade to complete from its conception in 2003, and scientists such as U.S. molecular biologist Richard H. Ebright expressed concern of previous escapes of the SARS virus at Chinese laboratories in Beijing, and the pace and scale of China's plans for expansion into BSL–4 laboratories.
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case at https://briansprediction.com/sabrina-demarcus-and-marcus-found
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Date(s) of Birth Used
Hair
Eyes
Height
Weight
Race
Reward:
secody_janson2
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Dream number 9618 21 November 2017 2 - archive.org @ http://bit.ly/2n4ABro
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Psychic Brian Ladd January 2020 dream by Brian Ladd - brianladd.org

Wuhan coronavirus pychic prediction

Wuhan coronavirus map

The 2019 novel coronavirus (2019-nCoV)[3][4], also known as the Wuhan coronavirus,[1] is a contagious virus that causes respiratory infection and has shown evidence of human-to-human transmission, first identified by authorities in Wuhan, Hubei, China, as the cause of the ongoing 2019-20 Wuhan coronavirus outbreak.[5] Genomic sequencing has shown that it is a positive-sense, single-stranded RNA coronavirus.[6][7][8]

Due to reports that the the initial cases had epidemiological links to a large seafood and animal market, the virus is thought to have a zoonotic origin, though this has not been confirmed.[9] Comparisons of genetic sequences between this virus and other existing virus samples have shown similarities to SARS-CoV (79.5%)[10] and bat coronaviruses (96%)[10], with a likely origin in bats being theorized.[11][12][13]


Contents
1 Epidemiology
2 Symptoms and treatment
3 Virology
3.1 Infection
3.2 Reservoir
3.3 Phylogenetics and taxonomy
4 Structural biology
5 Vaccine research
6 References
7 External links
Epidemiology
Main article: 2019–20 Wuhan coronavirus outbreak
The first known outbreak of 2019-nCoV was detected in Wuhan, China, in mid-December 2019. The virus subsequently spread to other provinces of Mainland China and other countries, including Thailand, Japan, Taiwan, South Korea, Australia, France, and the United States.[14][15][16]

As of 27 January 2020, there were 2,886 confirmed cases of infection, of which 2,825 were within mainland China.[17] Cases outside China, to date, were people who have either travelled from Wuhan, or were in direct contact with someone who travelled from the area.[18] The number of deaths was 81 as of 27 January 2020.[17] Human-to-human spread was confirmed in Guangdong, China, on 20 January 2020.[19]

Symptoms and treatment
Reported symptoms have included fever, fatigue, dry cough, shortness of breath, and respiratory distress.[20][21] Cases of severe infection can result in pneumonia, kidney failure, and death.[22] In a statement issued on 23 January 2020, WHO Director-General Tedros Adhanom Ghebreyesus stated that a quarter of those infected experienced severe disease, and that many of those who died had other conditions such as hypertension, diabetes, or cardiovascular disease that impaired their immune systems.[23] A study of the first 41 patients admitted to hospitals in Wuhan with confirmed cases reported that a majority of the patients were healthy before contracting the infection, and that over a quarter of previously healthy individuals required intensive care.[24][25] Among the majority of those hospitalised, vital signs were stable on admission, and they had low white blood cells counts and low lymphocytes.[21]

No specific treatment is currently available, so treatment is focused on alleviation of symptoms. Existing anti-virals are being studied,[26] including protease inhibitors like indinavir, saquinavir, remdesivir, lopinavir/ritonavir and interferon beta.[27]

Virology
Infection
Human-to-human transmission of the virus has been confirmed.[19] Reports have emerged that the virus is infectious even during the incubation period.[28][29] However, Nancy Messonnier, CDC director, states that "We at CDC don't have any evidence of patients being infectious prior to symptom onset." [30]

One research group has estimated the basic reproduction number ({displaystyle R_{0}}R_{0}) of the virus to be between 3 and 5,[31] meaning it typically infects 3 to 5 people per established infection. Other research groups have estimated the basic reproduction number to be between 1.4 and 3.8.[32] It has been established that the virus is able to transmit along a chain of at least four people.[33]

Reservoir
Animals sold for food are suspected to be the reservoir or the intermediary because many of the first identified infected individuals were workers at the Huanan Seafood Market. Consequently, they were exposed to greater contact with animals.[21] A market selling live animals for food was also blamed in the SARS epidemic in 2003; such markets are considered a perfect incubator for novel pathogens.[34]

With a sufficient number of sequenced genomes, it is possible to reconstruct a phylogenetic tree of the mutation history of a family of viruses. During 17 years of research on the origin of the SARS 2003 epidemic, many SARS-like bat coronaviruses were isolated and sequenced, most of them originating from the Rhinolophus genus of bats. The Wuhan novel coronavirus has been found to fall into this category of SARS-related coronaviruses. Two genome sequences from Rhinolophus sinicus published in 2015 and 2017 show a resemblance of 80% to 2019-nCoV.[11][12] A third unpublished virus genome from Rhinolophus affinis with a resemblance of 96% to 2019-nCoV has also been noted.[35] For comparison, this amount of variation among viruses is similar to the amount of mutation observed over ten years in the H3N2 human flu virus strain.[36]

Phylogenetics and taxonomy
Genomic information
2019-nCoV genome.svg
Genome organisation (click to enlarge)
NCBI genome ID MN908947
Genome size 30,473 bases
Year of completion 2020
2019-nCoV belongs to the broad family of viruses known as coronaviruses. Other coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as the Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), but only six were previously known to infect people; 2019-nCoV made it seven.[37]

The virus is genetically distinct from other known coronaviruses that infect humans, including severe acute respiratory syndrome-related coronavirus (SARS-CoV) and Middle East respiratory syndrome-related coronavirus (MERS-CoV).[8] Like SARS-CoV, it is a member of the subgenus Sarbecovirus (Beta-CoV lineage B).[38][21][39] Its RNA sequence is approximately 30 kb in length.[8]

By 12 January, five genomes of the novel coronavirus had been isolated from Wuhan and reported by the Chinese Center for Disease Control and Prevention and other institutions;[8][40][41] the number of genomes increased to 28 by 26 January. Except for the earliest GenBank genome, the genomes are under an embargo at GISAID. A phylogenic analysis for the samples is available through Nextstrain.[42]

Structural biology

Innophore Phyre2 ribbon diagram of 2019-nCoV protease, a prospective target for antiviral drugs[43]
The publications of the genome led to several protein modeling experiments on the receptor binding protein (RBD) of the nCoV spike (S) protein suggesting that the S protein retained sufficient affinity to the Angiotensin converting enzyme 2 (ACE2) receptor to use it as a mechanism of cell entry.[44] On 22 January, a group in China working with the full virus and a group in the U.S. working with reverse genetics independently and experimentally demonstrated ACE2 as the receptor for 2019-nCoV.[45][46][47]

To look for potential drugs, the viral protease M(pro) was also modeled for drug docking experiments. Innophore has produced two computational models based on SARS protease,[43] and the Chinese Academy of Sciences has produced an experimental structure of a recombinant 2019-nCoV protease.

Vaccine research


Coronaviruses are a group of viruses that cause diseases in mammals, including humans, and birds. In humans, the virus causes respiratory infections which are typically mild but, in rare cases, can be lethal. In cows and pigs they may cause diarrhea, while in chickens it can cause an upper respiratory disease. There are no vaccines or antiviral drugs that are approved for prevention or treatment.

Coronaviruses are viruses in the subfamily Orthocoronavirinae in the family Coronaviridae, in the order Nidovirales.[4][5] Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome and with a nucleocapsid of helical symmetry. The genomic size of coronaviruses ranges from approximately 26 to 32 kilobases, the largest for an RNA virus.

The name "coronavirus" is derived from the Latin corona and the Greek κορώνη (korṓnē, "garland, wreath"), meaning crown or halo. This refers to the characteristic appearance of virions (the infective form of the virus) by electron microscopy, which have a fringe of large, bulbous surface projections creating an image reminiscent of a royal crown or of the solar corona. This morphology is created by the viral spike (S) peplomers, which are proteins that populate the surface of the virus and determine host tropism.

Proteins that contribute to the overall structure of all coronaviruses are the spike (S), envelope (E), membrane (M) and nucleocapsid (N). In the specific case of the SARS coronavirus (see below), a defined receptor-binding domain on S mediates the attachment of the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2).[6] Some coronaviruses (specifically the members of Betacoronavirus subgroup A) also have a shorter spike-like protein called hemagglutinin esterase (HE).[4]


Contents
1 Human coronaviruses
1.1 Novel coronavirus (2019-nCoV)
1.2 Severe acute respiratory syndrome (SARS)
1.3 Middle East respiratory syndrome
2 Replication
3 Taxonomy
4 History
4.1 Evolution
5 Other animals
5.1 Diseases caused
5.2 In domestic animals
6 See also
7 References
8 Further reading
9 External links
Human coronaviruses
Coronaviruses are believed to cause a significant percentage of all common colds in human adults and children. Coronaviruses cause colds with major symptoms, e.g. fever, throat swollen adenoids, in humans primarily in the winter and early spring seasons.[7] Coronaviruses can cause pneumonia, either direct viral pneumonia or a secondary bacterial pneumonia and they can also cause bronchitis, either direct viral bronchitis or a secondary bacterial bronchitis.[8] The much publicized human coronavirus discovered in 2003, SARS-CoV which causes severe acute respiratory syndrome (SARS), has a unique pathogenesis because it causes both upper and lower respiratory tract infections.[8]

There are seven strains of human coronaviruses:

Human coronavirus 229E (HCoV-229E)
Human coronavirus OC43 (HCoV-OC43)
SARS-CoV
Human coronavirus NL63 (HCoV-NL63, New Haven coronavirus)
Human coronavirus HKU1
Middle East respiratory syndrome coronavirus (MERS-CoV), previously known as novel coronavirus 2012 and HCoV-EMC.
Novel coronavirus (2019-nCoV),[9][10] also known as Wuhan pneumonia or Wuhan coronavirus.[11] ('Novel' in this case means newly discovered, or newly originated, and is a placeholder name.) [10]
The coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 continually circulate in the human population and cause respiratory infections in adults and children world-wide.[12]

Novel coronavirus (2019-nCoV)
Cross-sectional model of a coronavirus
Cross-sectional model of a coronavirus
The 2019–20 China pneumonia outbreak in Wuhan was traced to a novel coronavirus,[13] which is labeled as 2019-nCoV by WHO.[9][10]

Severe acute respiratory syndrome (SARS)
Main article: Severe acute respiratory syndrome
In 2003, following the outbreak of severe acute respiratory syndrome (SARS) which had begun the prior year in Asia, and secondary cases elsewhere in the world, the World Health Organization (WHO) issued a press release stating that a novel coronavirus identified by a number of laboratories was the causative agent for SARS. The virus was officially named the SARS coronavirus (SARS-CoV). Over 8,000 people were infected, about 10% of whom died.[6]

Middle East respiratory syndrome
Main article: Middle East respiratory syndrome
In September 2012, a new type of coronavirus was identified, initially called Novel Coronavirus 2012, and now officially named Middle East respiratory syndrome coronavirus (MERS-CoV).[14][15] The World Health Organization issued a global alert soon after.[16] The WHO update on 28 September 2012 stated that the virus did not seem to pass easily from person to person.[17] However, on 12 May 2013, a case of human-to-human transmission in France was confirmed by the French Ministry of Social Affairs and Health.[18] In addition, cases of human-to-human transmission have been reported by the Ministry of Health in Tunisia. Two confirmed cases involved people who seemed to have caught the disease from their late father, who became ill after a visit to Qatar and Saudi Arabia. Despite this, it appears that the virus has trouble spreading from human to human, as most individuals who are infected do not transmit the virus.[19] By 30 October 2013, there were 124 cases and 52 deaths in Saudi Arabia.[20]

After the Dutch Erasmus Medical Centre sequenced the virus, the virus was given a new name, Human Coronavirus–Erasmus Medical Centre (HCoV-EMC). The final name for the virus is Middle East respiratory syndrome coronavirus (MERS-CoV). In May 2014, the only two United States cases of MERS-CoV infection were recorded, both occurring in healthcare workers who worked in Saudi Arabia and then traveled to the U.S. One was treated in Indiana and one in Florida. Both of these individuals were hospitalized temporarily and then discharged.[21]

In May 2015, an outbreak of MERS-CoV occurred in the Republic of Korea, when a man who had traveled to the Middle East, visited 4 different hospitals in the Seoul area to treat his illness. This caused one of the largest outbreaks of MERS-CoV outside of the Middle East.[22] As of December 2019, 2,468 cases of MERS-CoV infection had been confirmed by laboratory tests, 851 of which were fatal, a mortality rate of approximately 34.5%.[23]

Replication

The infection cycle of coronavirus
Following the entry of this virus into the cell, the virus particle is uncoated and the RNA genome is deposited into the cytoplasm.

The coronavirus RNA genome has a 5′ methylated cap and a 3′ polyadenylated tail. This allows the RNA to attach to ribosomes for translation.

Coronaviruses also have a protein known as a replicase encoded in its genome which allows the RNA viral genome to be transcribed into new RNA copies using the host cell's machinery. The replicase is the first protein to be made; once the gene encoding the replicase is translated, the translation is stopped by a stop codon. This is known as a nested transcript. When the mRNA transcript only encodes one gene, it is monocistronic. A coronavirus non-structural protein provides extra fidelity to replication because it confers a proofreading function,[24] which is lacking in RNA-dependent RNA polymerase enzymes alone.

The RNA genome is replicated and a long polyprotein is formed, where all of the proteins are attached. Coronaviruses have a non-structural protein – a protease – which is able to separate the proteins in the chain. This is a form of genetic economy for the virus, allowing it to encode the greatest number of genes in a small number of nucleotides.[25]
Jan 27, 2021 at 11:17 PM